Is COVID-19 injection-induced myocarditis mild and transient? Nope.
by Jessica Rose | May 8, 2022
John Su works for the Immunization Safety Office Centers for Disease Control and Prevention (CDC) and Tom Shimabukuro works for the U.S. Department of Health and Human Services (HHS) and the CDC. They both make the claim in their Advisory Committee on Immunization Practices (ACIP) presentations that myocarditis (sometimes called myopericarditis) is not a problem, despite its prevalence in the context of the COVID-injectable products. Especially in children.
Just to give my readers an idea of the above-background reporting per age group, here’s a slide from Shimabukuro’s presentation. And yes, he really did present this to the FDA and yes, they still said everything’s fine. I didn’t even have to highlight anything: he did it for us.
This chart indicates that even if we take the highest expected value for males, the observed value is still 11 times higher. If we take the lowest value, it’s 132 times higher. On average, the observed rate is 20 times the expected in boys ages 12-17. You get the drift.
I made the following slide that anyone and everyone can use. As I have explained in many of my interviews, myocarditis is inflammation of the myocardium of the heart. This is the muscly part of the heart that allows the heart to beat. Beating is important for the movement of blood throughout the circulatory system. It is as yet unclear to me as to whether the blood pumps the heart or if the heart pumps the blood. I tend to think it is the former, but I digress.
The myocardium contains specialized cells called cardiomyocytes or myocardiocytes. Or cytecardiomyos or cardiB-o-cytes. Just kiddingabout the last two. Cardi-B-omyocytes are some of the first cells to terminally-differentiate in human development, which is why we can detect a heart beat on an ultrasound of a human fetus. These cells are interconnected, elongated, cylindrical and striated with contractile proteins and most have a single nucleus. Below is a photo! Are they not the most beautiful things you’ve ever seen? Aw, immuno-staining. Where would we be without you.1
While cardiomyocytes appear to continue to renew throughout life, the quantitatively dominant mechanism of growth in the mammalian postnatal heart is an increase in cardiomyocyte size (reviewed in Heineke et al).4
It is well known now via peer-reviewed literature5 (footnote 4 gives 31 reference sources – pretty up-to-date) that the COVID-19 injectable products are heavily-associated with (that be code for ‘caused by’ me mateys) [autoimmune] myocarditis. This would be the result of foreign proteins embedded or displayed on cell surfaces by MHC-class I and II molecules for presentation to specific immune cells designed to target and destroy cells flagged with such foreign proteins. Footnote reference ‘6’ is a really good paper to read about this subject. They discuss Sarcoidosis which everyone knows about because of House M.D..6
COVID-19 injection-induced myocarditis results in scar tissue replacing the damaged myocytes and this scar tissue does not have contractile function. This is what Su and Shimabukuro refer to as “recovery”. You know, the kid is still alive, it’s just that their heart has fewer functional myocytes now. Imagine you blew up a balloon after putting small pieces of tape on the surface. Those spots where the tape are would not be able to stretch and that would put extra strain and pressure on the rubbery or contractile parts of the balloon surface. Eventually, the strain would be too much and the balloon would pop from additional pressure.
Popping of heart. Where have I heard of that happening before?
In any case, I could ramble on about this, but my new paper’s coming soon so you can read my ramblings then. And the slide says it all.
This is NOT mild and NOT transient. They are LYING.
Thank you to a Twitter person for this link to a video entitled “The inflammation of the heart muscle caused by SARS Cov 2 vaccine”.
Keepers, B., Liu, J., & Qian, L. (2020). What’s in a cardiomyocyte – And how do we make one through reprogramming?. Biochimica et biophysica acta. Molecular cell research, 1867(3), 118464. https://doi.org/10.1016/j.bbamcr.2019.03.011.
Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA. Cardiomyocyte Regeneration: A Consensus Statement. Circulation. 2017 Aug 15;136(7):680-686. doi: 10.1161/CIRCULATIONAHA.117.029343. Epub 2017 Jul 6. PMID: 28684531; PMCID: PMC5557671.
Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7:589–600.
1. Abbate, A., Gavin, J., Madanchi, N., Kim, C., Shah, P. R., Klein, K., Boatman, J., Roberts, C., Patel, S., & Danielides, S. (2021). Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients. International journal of cardiology, 340, 119–121. https://doi.org/10.1016/j.ijcard.2021.08.018.
2. Abu Mouch S., et al. Myocarditis following COVID-19 mRNA vaccination. Vaccine. 2021;39(29):3790–3793. doi: 10.1016/j.vaccine.2021.05.087. PMID: 34092429; PMC8162819.
3. Albert E, Aurigemma G, Saucedo J, Gerson DS. Myocarditis following COVID-19 vaccination. Radiol Case Rep. 2021;16(8):2142-2145. doi:10.1016/j.radcr.2021.05.033.
4. Al-Rasbi, S. et al. (2022). Myocarditis, Pulmonary Hemorrhage, and Extensive Myositis with Rhabdomyolysis 12 Days After First Dose of Pfizer-BioNTech BNT162b2 mRNA COVID-19 Vaccine: A Case Report. The American journal of case reports, 23, e934399. https://doi.org/10.12659/AJCR.934399.
5. Badshah, M., Shriver, J., Rynders, B., Sjovold, A., Shaukat, M., & Rajpurohit, N. (2021). MODERNA mRNA-1273 vaccine-associated myopericarditis in a patient with a subclinical autoimmune predisposition. Journal of cardiology cases, 24(5), 227–229. https://doi.org/10.1016/j.jccase.2021.09.007.
6. Bozkurt B, Kamat I, Hotez PJ. Myocarditis With COVID-19 mRNA Vaccines. Circulation. 2021 Aug 10;144(6):471-484. doi: 10.1161/CIRCULATIONAHA.121.056135. Epub 2021 Jul 20. PMID: 34281357; PMCID: PMC8340726.
7. Can Li, et al. Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model, Clinical Infectious Diseases, 2021, ciab707, https://doi.org/10.1093/cid/ciab707.
8. Chamling B, et al. Occurrence of acute infarct-like myocarditis following COVID-19 vaccination: just an accidental co-incidence or rather vaccination-associated autoimmune myocarditis? Clin Res Cardiol. 2021 Jul 31:1–5. doi: 10.1007/s00392-021-01916-w. Epub ahead of print. PMID: 34333695; PMCID: PMC8325525.
9. Chelala L, Jeudy J, Hossain R, Rosenthal G, Pietris N, White CS. Cardiac MRI Findings of Myocarditis After COVID-19 mRNA Vaccination in Adolescents. AJR Am J Roentgenol. 2022 Apr;218(4):651-657. doi: 10.2214/AJR.21.26853. Epub 2021 Oct 27. PMID: 34704459.
10. Das BB, Moskowitz WB, Taylor MB, Palmer A. Myocarditis and Pericarditis Following mRNA COVID-19 Vaccination: What Do We Know So Far? Children (Basel). 2021 Jul 18;8(7):607. doi: 10.3390/children8070607. PMID: 34356586; PMCID: PMC8305058.
11. Das BB, et al. Myopericarditis after messenger RNA Coronavirus Disease 2019 Vaccination in Adolescents 12 to 18 Years of Age. J Pediatr. 2021 Nov;238:26-32.e1. doi: 10.1016/j.jpeds.2021.07.044. Epub 2021 Jul 30. PMID: 34339728; PMCID: PMC8321962.
12. Diaz GA, Parsons GT, Gering SK, Meier AR, Hutchinson IV, Robicsek A. Myocarditis and Pericarditis After Vaccination for COVID-19. JAMA. 2021;326(12):1210–1212. doi:10.1001/jama.2021.13443.
13. Dionne, A., Sperotto, F., Chamberlain, S., Baker, A. L., Powell, A. J., Prakash, A., Castellanos, D. A., Saleeb, S. F., de Ferranti, S. D., Newburger, J. W., & Friedman, K. G. (2021). Association of Myocarditis With BNT162b2 Messenger RNA COVID-19 Vaccine in a Case Series of Children. JAMA cardiology, 6(12), 1446–1450. https://doi.org/10.1001/jamacardio.2021.3471.
14. Frustaci, A., Verardo, R., Galea, N., Lavalle, C., Bagnato, G., Scialla, R., & Chimenti, C. (2022). Hypersensitivity Myocarditis after COVID-19 mRNA Vaccination. Journal of clinical medicine, 11(6), 1660. https://doi.org/10.3390/jcm11061660.
15. Harris KM, Mackey-Bojack S, Bennett M, Nwaudo D, Duncanson E, Maron BJ. Sudden Unexpected Death Due to Myocarditis in Young People, Including Athletes. Am J Cardiol. 2021 Mar 15;143:131-134. doi: 10.1016/j.amjcard.2020.12.028. Epub 2020 Dec 19. PMID: 33347841.
16.Hudson B, Mantooth R, DeLaney M. Myocarditis and pericarditis after vaccination for COVID-19. J Am Coll Emerg Physicians Open. 2021 Jul 26;2(4):e12498. doi: 10.1002/emp2.12498. PMID: 34337595; PMCID: PMC8313036.
17. Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ. Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination. JAMA Cardiol. 2021 Jun 29:e212828. doi: 10.1001/jamacardio.2021.2828. Epub ahead of print. PMID: 34185046; PMCID: PMC8243258.
18. Luk A, et al. Myocarditis and Pericarditis following COVID-19 mRNA Vaccination: Practical Considerations for Care Providers. Can J Cardiol. 2021 Aug 7:S0828-282X(21)00624-3. doi: 10.1016/j.cjca.2021.08.001. Epub ahead of print. PMID: 34375696; PMCID: PMC8349442.
19. Mei R, Raschi E, Forcesi E, Diemberger I, De Ponti F, Poluzzi E. Myocarditis and pericarditis after immunization: Gaining insights through the Vaccine Adverse Event Reporting System. Int J Cardiol. 2018 Dec 15;273:183-186. doi: 10.1016/j.ijcard.2018.09.054. Epub 2018 Sep 14. PMID: 30236504.
20.Montgomery J, et al. Myocarditis Following Immunization With mRNA COVID-19 Vaccines in Members of the US Military. JAMA Cardiol. 2021 Jun 29. doi: 10.1001/jamacardio.2021.2833. Epub ahead of print. PMID: 34185045.
21.Nassar M, Nso N, Gonzalez C, et al. COVID-19 vaccine-induced myocarditis: Case report with literature review [published correction appears in Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102277]. Diabetes Metab Syndr. 2021; 15(5):102205. doi:10.1016/j.dsx.2021.102205.
22. Parmar, K., Mekraksakit, P., Del Rio-Pertuz, G., Sethi, P., Motes, A., Hughes, M., Wischmeyer, J., Carbajal, L., & Sosa, E. A. (2021). Myocarditis following COVID-19 mRNA vaccination. Proceedings (Baylor University. Medical Center), 35(2), 209–213. https://doi.org/10.1080.
23. Salah HM, Mehta JL. COVID-19 Vaccine and Myocarditis. Am J Cardiol. 2021 Jul 12:S0002-9149(21)00639-1. doi: 10.1016/j.amjcard.2021.07.009. Epub ahead of print. PMID: 34399967; PMCID: PMC8272967.
24. Schauer J, et al. Persistent Cardiac MRI Findings in a Cohort of Adolescents with post COVID-19 mRNA vaccine myopericarditis, The Journal of Pediatrics (2022), doi: https:// doi.org/10.1016/j.jpeds.2022.03.032.
25. Schmitt, P., Demoulin, R., Poyet, R., Capilla, E., Rohel, G., Pons, F., Jégo, C., Sidibe, S., Druelle, A., Brocq, F. X., Dutasta, F., & Cellarier, G. R. (2021). Acute Myocarditis after COVID-19 vaccination: A case report. La Revue de medecine interne, 42(11), 797–800. https://doi.org/10.1016/j.revmed.2021.10.003.
26. Shaw KE, Cavalcante JL, Han BK, Gössl M. Possible Association Between COVID-19 Vaccine and Myocarditis: Clinical and CMR Findings. JACC Cardiovasc Imaging. 2021 Jun 16:S1936-878X(21)00485-X. doi: 10.1016/j.jcmg.2021.06.002. Epub ahead of print. PMID: 34246586; PMCID: PMC8245050.
27. Singh B, Kaur P, Cedeno L, Brahimi T, Patel P, Virk H, Shamoon F, Bikkina M. COVID-19 mRNA Vaccine and Myocarditis. Eur J Case Rep Intern Med. 2021 Jun 14;8(7):002681. doi: 10.12890/2021_002681. PMID: 34268277; PMCID: PMC8276934.
28. Truong DT, et al. Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults. Circulation. 2021 Dec 6. doi: 10.1161/CIRCULATIONAHA.121.056583. PMID: 34865500.
29. Tsilingiris, D., Vallianou, N. G., Karampela, I., Liu, J., & Dalamaga, M. (2022). Potential implications of lipid nanoparticles in the pathogenesis of myocarditis associated with the use of mRNA vaccines against SARS-CoV-2. Metabolism open, 13, 100159. https://doi.org/10.1016/j.metop.2021.100159.
30. Vidula MK, Ambrose M, Glassberg H, Chokshi N, Chen T, Ferrari VA, Han Y. Myocarditis and Other Cardiovascular Complications of the mRNA-Based COVID-19 Vaccines. Cureus. 2021 Jun 10;13(6):e15576. doi: 10.7759/cureus.15576. PMID: 34277198; PMCID: PMC8270057.
31. Won, T., Gilotra, N. A., Wood, M. K., Hughes, D. M., Talor, M. V., Lovell, J., Milstone, A. M., Steenbergen, C., & Čiháková, D. (2022). Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination. Frontiers in immunology, 13, 851620. https://doi.org/10.3389/fimmu.2022.851620.
Bracamonte-Baran, W., & Čiháková, D. (2017). Cardiac Autoimmunity: Myocarditis. Advances in experimental medicine and biology, 1003, 187–221. https://doi.org/10.1007/978-3-319-57613-8_10.
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